1H-Indole-3-methanamine, N,N,2-trimethyl-

1H-Indole-3-methanamine, N,N,2-trimethyl- - Names and Identifiers

Name	N,N-dimethyl-1-(2-methyl-1H-indol-3-yl)methanamine
Synonyms	2-METHYLGRAMINE 3-(DIMETHYLAMINOMETHYL)-2-METHYLINDOLE 2-Methyl-3-N,N-dimethylaminomethylindole 2-METHYL-3-N,N-DIMETHYLAMINOMETHYLINDOLE 1H-Indole-3-methanamine, N,N,2-trimethyl- DIMETHYL-(2-METHYL-1H-INDOL-3-YLMETHYL)-AMINE N,N-dimethyl-1-(2-methyl-1H-indol-3-yl)methanamine N,N-Dimethyl-1-(2-methyl-1H-indol-3-yl)methanamine
CAS	37125-92-1
InChI	InChI=1/C12H16N2/c1-9-11(8-14(2)3)10-6-4-5-7-12(10)13-9/h4-7,13H,8H2,1-3H3

1H-Indole-3-methanamine, N,N,2-trimethyl- - Physico-chemical Properties

Molecular Formula	C12H16N2
Molar Mass	188.27
Density	1.077±0.06 g/cm3(Predicted)
Melting Point	120-121 °C(Solv: acetone (67-64-1); ethanol (64-17-5))
Boling Point	133-134 °C(Press: 1.5 Torr)
Flash Point	141.1°C
Vapor Presure	0.000631mmHg at 25°C
pKa	17.57±0.30(Predicted)
Refractive Index	1.618

1H-Indole-3-methanamine, N,N,2-trimethyl- - Introduction

N,N-dimethyl-1-(2-methyl-1H-indol-3-yl)methanamine, also known as N,N-dimethyl-1-(2-methylindol-3-yl) methylamine, is an organic compound. The following is a brief description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless to yellow crystalline solid
-Solubility: Soluble in organic solvents such as alcohol, ether and chloride solution
-Melting point: approx. 85-88°C
-Molecular formula: C13H18N2
-Molecular weight: 202.30g/mol

Use:
-Drug synthesis: N,N-dimethyl-1-(2-methyl-1H-indol-3-yl)methanamine is a drug intermediate, which can be used to synthesize anti-tumor, antipsychotic and antidepressant drugs.

Preparation Method:
N,N-dimethyl-1-(2-methyl-1H-indol-3-yl)methanamine can be prepared by the following steps:
1. Condensation reaction of 2-methylindole and methylamine in an appropriate solvent.
2. Hydrochloric acid is added to salinize the condensation product.
3. The salt is treated with alkali to generate N,N-dimethyl-1-(2-methyl-1H-indol-3-yl)methanamine.

Safety Information:
-Limited information on toxicity to humans, but use with caution and avoid contact with eyes, skin and inhalation.
-Wear personal protective equipment such as lab gloves, goggles, and lab coats when using and handling this compound.
-A suitable gas extraction or ventilation system should be observed to ensure that there is sufficient fresh air in the operating environment.
-Please store properly and avoid contact with oxidants, acids and alkalis.

This is only a brief overview of the N,N-dimethyl-1-(2-methyl-1H-indol-3-yl)methanamine. For specific information and operations, refer to the relevant chemical literature or consult professionals.

Last Update：2024-04-09 02:00:45